77 PAPER Gait apraxia after bilateral supplementary motor area lesion S Della Sala, A Francescani, H Spinnler ............................................................................................................................. J Neurol Neurosurg Psychiatry 2002;72:77–85 See end of article for authors’ affiliations (The authors are listed in alphabetical order) ....................... Correspondence to: Professor S Della Sala, Department of Psychology, University of Aberdeen, AB24 2 UB Aberdeen, UK; sergio@abdn.ac.uk Received 3 April 2001 In revised form 28 August 2001 Accepted 3 September 2001 ....................... Objectives: The study aimed at addressing the issue of the precise nature of gait apraxia and the cerebral dysfunction responsible for it. Methods: The case of a patient, affected by a bilateral infarction limited to a portion of the anterior cerebral artery territory is reported. The patient’s ability to walk was formally assessed by means of a new standardised test. Results: Due to an anomaly within the anterior cerebral artery system, the patient’s lesion was centred on the supplementary motor regions of both hemispheres. He presented with clear signs of gait apraxia that could not be accounted for by paresis or other neurological deficits. No signs of any other form of apraxia were detected. Conclusions: The clinical profile of the patient and the analysis of 49 cases from previous literature suggest that gait apraxia should be considered a clinical entity in its own right and lesions to the supplementary motor areas are responsible for it. G ait disorders are a common feature of several neurological (for example, Parkinson’s disease) and psychiatric diseases (for example, schizophrenia). Disturbances of gait that cannot be readily accounted for by abnormalities often occurring in old age (for example, bone and joint degeneration, muscle wasting, or arteriosclerosis obliterans of the lower limbs), pyramidal or sensorial deficits, ataxia (cerebellar, vestibular, or proprioceptive), dystonias or dyskinesias (due to diseases involving the basal ganglia), nor by psychosis, are often referred to as “gait apraxia”(GA)*.20–24 Meyer and Barron23 defined GA as “the loss of ability to properly use the lower limbs in the act of walking” (p 279). The syndrome is composed of a mixture of signs including disequilibrium, locomotor abnormalities, inappropriate postural responses, and loss of gait ignition. Gait, stance, and trunk movements are all complex and highly practised.25 The respective contribution of each one of these components is often hard to disentangle from that of the others (Rumpf, Stand und Gangapraxie, trunk, stance, and gait apraxia6 26). Indeed, Lange27 maintained that in GA ideomotor apraxia of limbs is not relevant and that all segments involved intertwine to perform a given movement. Moreover, Nutt et al20 maintained that the severity of each individual sign constituting gait apraxia varies from patient to patient. ............................................................. *The syndrome of GA has been named differently by different authors—for example, “Torso apraxie” (trunk apraxia1) or “déséquilibration frontale” (frontal imbalance2). Some of the other labels conformed to the core deficit found—for example, “trepidante abasie”,3 4 “eingentümliche Ungeschicklichkeit” (remarkable clumsiness5), “bewegungstechnische Schwierigkeit” (loss of the technical requirements of the movements6), “Tapsigkeit” (gawky movements7), “Unbeholfenheit” (awkwardness8), slipping clutch syndrome,9 lower half parkinsonism,10 11 gait ignition failure.12 Some other labels referred to the authors’ interpretation of GA—for example, melokinetic apraxia,13 “frontale ataxie” (frontal ataxia14), “gliedkinetische apraxie” (limb-kinetic apraxia, quoted by Westphal,15 “motorische Apraxie”,16 “corticale apraxie”,17 “innervatorische Apraxie” (innervatory apraxia6), “bilaterale motorische Apraxie”,18 19 frontal gait disorder,20 higher level gait disorder.21 However, these different terms, often derived from different conceptualisations of gait disorders, define syndromes that overlap more than is usually admitted. The trunk component of GA encompasses disturbances such as deficits of rising from sitting, sitting down, lying down, turning around while standing, or rolling over in bed. Disturbances of stance encompass deficits of balance while either standing in an upright position, walking, or in negotiating turns. They also include the loss of anticipatory and reactive postural responses resulting in falls.22 28 Gait disorders comprise deficits of ignition (frozen foot) and stepping, including shuffling, obstructive leg crossing,22 29 or leg hypokinesia. Other signs characterising gait disruption include bizarre, counterproductive, and perseverative leg movements, such as the leg’s Witzelsucht,29 dystonias, dyskinesias, and lower limbs hypotonia as well as involuntary temporary arrests of walking. Some authors interpreted GA as a feature of frontal inertia.30 Others31 maintained that GA be a misnomer as the deficit should not be interpreted as apraxic.32–34 Gait apraxia was seen over a century ago in patients with lesions to the precentral regions of the frontal lobes who were not paretic.14* The association between GA and lesions to the frontal lobes has been reiterated ever since.2 23 25 37 Moreover, a few authors38–42 demonstrated that the link between trunk movement disturbances and left parietal lesions is weak with respect to other apraxias (but see Poeck et al43 for a different view). However, the precise nature of GA and the cerebral dysfunction responsible for it have been matters of considerable debate.7 28 44 45 The association between gait disturbances ............................................................. *Bruns14 quoted the work of earlier authors who noted the presence of stance and gait disorders in patients with frontal tumours. Among them, he (p 138) cited Wernicke35 who reckoned that a “hesitant gait has been often seen in patients with frontal tumours, it is well possible that in the future this sign will be considered as resulting from a direct insult to the frontal lobes” (p 323). Oppenheim36 described gait disturbances in nine of 11 patients with frontal tumours compared with only four of 10 patients with tumours elsewhere in the brain. Bernhardt (quoted by Bruns14 p 138) reported gait disturbances in 18 of 44 patients (40%) with frontal tumours but only in five of 41 (5%) patients with extrafrontal tumours. This testifies that the link between gait disturbances and frontal lesions predates the later discussion between its apraxic or ataxic nature. www.jnnp.com 78 and cerebellar damage has been the only accepted knowledge for a long time. Neurosurgeons searched for tumours in the cerebellum solely on the basis of the ataxic appearance of GA,46 47 only to discover postmortem that sometimes the tumour was sited within the frontal lobes instead. Some early authors,16 48 49 following Bruns’14 suggestion, maintained that the symptoms of GA could aptly be explained in terms of cerebellar imbalance. They interpreted it as due to either a frontopontocerebellar disconnection,50 51 or to an increased pressure which benumbs the cerebellum.52 Frazier49 maintained “that ataxia may be caused by a unilateral or a bilateral frontal lobe even in the absence of signs of increased intracranial pressure seems to admit of no contradiction” (p554). Hence the term “frontal ataxia” became popular. De Ajuriaguerra et al53 conceded that GA may be a sign of frontal involvement, though denied that it was apraxic in nature. On the other hand, Hartmann54 and Kleist6 conceived that the GA movement disorders be a form of true apraxia, due to lesion of a specific frontal centre devoted to deploying attention to negotiate gait or to the planning of trunk and lower limb movements, respectively. Crigel and Arseni55 studied 165 patients with either unilateral or bilateral frontal damage, 59 (36%) of whom presented with gait disorganisation. They argued that the walking disturbances due to frontal apraxia or cerebellar ataxia could be differentiated from one another (see also table 2 in Meyer and Barron23). The concept of GA met with significant agreement1 2 19 22 28 29 56–62 and is currently listed among the direct signs of frontal lobe damage (Adams et al63 pp 121–122; Kurlan et al64). The precise localisation of GA within the frontal lobes remains elusive. Reviews of the early literature showed that most cases of GA involved tumours encroaching on or compressing the medial aspects of the frontal cortex bilaterally.9 23 However, the mapping of the symptoms onto the damage caused by a tumour is far from adequate. Cases have also been reported of GA after vascular lesions, which should allow for a more precise localisation than allowed by tumours.6 19 23 25 28 57 65 66 Taken together this literature confirms that lesions to the medial walls of the frontal lobes are very likely to be responsible for the appearance of GA. In particular, the lesions found in these patients lay within the territory of the anterior cerebral arteries and softened the first frontal gyrus or the gyrus cinguli, with or without involving the corpus callosum. However, the lesions in these patients were either too large or not analysed in sufficient detail to allow firm conclusions about the precise identification of the structure the lesion of which may be responsible for GA. Moreover, although the clinical syndrome had been recognised long before,35 most reports of GA relied on a welter of signs never assembled in a formal diagnostic tool. In this paper we report the case of a patient who was affected by a bilateral infarction of a portion of the anterior cerebral artery territory. The patient showed a clear GA, which was formally investigated with a new and standardised test (Della Sala et al, unpublished data). An unusual anomaly of the anterior cerebral artery system of the patient caused his stroke to affect only the first frontal gyri of both hemispheres. This allowed us to better delineate the boundaries of the lesion sufficient and necessary to give rise to GA. CASE REPORT The patient was a right handed (score 12/12 on the handedness Edinburgh inventory67) retired man with 6 years of formal education. He was 64 years old when he was admitted to the third neurological ward of the University of Milan because of a bilateral stroke in the anterior cerebral arteries system. Clinical picture Two days after admission, He showed a spastic paraplegia with bilateral sign of pyramidal impairment, coupled with severe www.jnnp.com Della Sala, Francescani, Spinnler hypophonia. Neurological examination disclosed also the presence of plantal grasp, of bilateral “tonic grasping”,68 instances of groping (“magnetic apraxia”69) particularly with his right hand, and frontal release signs, such as bilateral palmomental and snout reflexes.70 He also presented with motor and verbal inertia.71 72 One month after the onset, the patient was able to walk with two crutches. Five months later his muscle stretch reflexes were still hyperactive in the lower limbs, although only minimal strength impairment was noticeable at the neurological examination. He had considerable difficulty in stopping walking on command and his gait, tentative and uncertain, was hampered by hesitation; in Liepmann’s73 terminology, he seemed to have lost the “Virtuosität” of the normal gait. Fourteen months after the patient’s stroke, the neurological examination disclosed only a minimal strength deficit on the right side. His walking remained very clumsy. He could not imitate foot/leg movements performed by the examiner (for example, draw a circle with the leg extended while seated, or trace a cross on the floor with either foot). Neuroradiology A series of MRIs and a digital subtraction angiography disclosed a particular anomaly in the patient’s anterior cerebral artery system, which supplies the medial surfaces of the frontal lobes. There are no right and left anterior cerebral arteries. His anterior vascular system is characterised by the presence of three main azygous-like trunks, one anterior, one middle, and one posterior, each one of which divides into a left and a right branch. From this vascular distribution derives the rare event that small symmetric areas of the medial surfaces of the right and left hemispheres are supplied by the same single artery. The patient had an occlusion of the middle trunk just before its partition, which gave rise to a stroke damaging symmetric portions of the medial walls of both of his frontal lobes. The lesion involved the superior frontal convolution (F1) of both hemispheres, sparing the polar regions, as well as the cingulate and the corpus callosum. In particular, it involved the supplementary motor areas (Brodmann’s area 6) of both sides (figs 1, 2, and 3). General neuropsychological assessment The patients neuropsychological assessment has been detailed elsewhere.74 In brief, he was fully oriented and cooperative, was not aphasic, and did not show any impairment in visual perception. His scores on tests assessing general intelligence and different aspects of memory functions were all within the normal range. When first assessed, 2 months after onset, he performed poorly on some tests assessing executive functions, such as phonological fluency, reversal learning, or selective attention, which have all been shown to be sensitive to frontal lobe damage.75 However, 14 months after onset his psychometric profile was entirely within the limits of normality. He also showed several instances of utilisation behaviour76 77 and grasp reflex, which were still persistent at this time. Apraxia assessment Imitation of intransitive gestures The test devised by De Renzi et al78 was employed. This is a 24 item imitation test consisting of half meaningful and half meaningless movements, half requiring the patient to hold a posture, and half the execution of a motor sequence. The score for each item ranges from 3 to 1 depending on whether the performance is flawless on the first, second, or third attempt. A score of zero is given when the performance is unsatisfactory all three times. Therefore the total score ranges from 0 to 72. Individual scores are age and education adjusted. The cut off point (53) corresponds to the worst score found in a group of 187 controls79 and represents the 95% outer tolerance limit of the normal population. Gait apraxia 79 Figure 1 The patient’s MRI T2 axial scans showing the lesion encroaching upon the superior frontal convolutions and centred on the SMA bilaterally. Actual use of objects The test described by De Renzi and Lucchelli68 was used. Twenty objects of common use were presented one at a time to the patient. He was asked to demonstrate their use by carrying out a series of common, complex actions (for example a candle, a candlestick, and a matchbox were laid on the table and the patient was asked to light the candle). Scoring followed the published norms, score ranges from 0 to 120, cut off score is 60 (worst observed score in normal controls). Face apraxia Two tests assessing the imitation of the upper and the lower face movements respectively were used.80 81 The upper face apraxia test included nine items (for example, “Close your eyes”, “Look down”), and the lower face apraxia test was made up of 29 items (for example, “Show your teeth”, “Blow”). Items were scored as pass or fail according to a set of rules derived from previous authors’ attempts to define errors in facial apraxia.82 83 For both the upper and lower face tests, scoring procedures based on the rank order score were employed. The total score ranges from a worst of zero to a best score of 45.0 in the upper face apraxia test and to a best of 435.0 in the lower face apraxia test. Individual scores are age and education adjusted. Cut off scores, corresponding to the outer tolerance limit of the score distribution of 182 healthy volunteers80 81 are 38 and 400 for upper and lower face tests respectively. The patient performed within the normal range on all tests assessing ideomotor, object utilisation, and upper and lower face apraxia. His scores are given in table 1. Gait apraxia The patient presented with difficulties in sitting on or standing from a chair on command. He had difficulty lying supine on the examining bed and could not roll over. These difficulties were also overt in his daily life. Indeed, his wife confirmed that he needed her assistance to go to bed and to rise from it. His walking was hesitant and at times he persevered with individual components of a movement sequence. He was well aware of these difficulties and understood what he was requested to do, although he upheld that he no longer knew how to perform these movements. These problems were initially traced back to his motor inertia and central paraplegia. However, these difficulties continued after the rapid recovery from his motor deficits (probably due to perilesional oedema) was almost complete. Indeed, the improvement of motor functions made it clear that he also had problems in starting to walk, in stopping going forward, let alone in trying to walk backwards. These deficits were so severe as to be far beyond the possible sequelae of some elementary neurological deficits. He did not show any cerebellar or parkinsonian signs or symptoms. Pseudobulbar palsy was highly unlikely as he was not dysphagic nor dysarthric, showed no signs of diffuse cognitive deterioration, and the MRI disclosed no signs of subcortical lacunae. Figure 2 The patient’s MRI T1 parasagittal scans. Left: parasagittal scan 2 mm off the midline. Right: parasagittal scan 5 mm off the midline. www.jnnp.com 80 Della Sala, Francescani, Spinnler 6 8 9 9 32 24 38 11 12 11 44 44 45 24 47 24 24 24 24 45 9 9 47 11 11 12 38 6 6 4 4 24 24 5 22 22 21 28 21 28 22 28 21 20 20 5 5 5 23 21 36 36 4 40 5 22 20 20 23 23 40 40 40 23 23 23 22 22 22 4 4 21 20 28 28 36 36 20 22 21 21 20 28 28 36 36 21 20 Figure 3 The patient’s MRI coronal scans were mapped onto standard templates following a standard procedure.116 Numbers refer to Brodmann’s areas. The lesions affected the medial aspects of the frontal lobes bilaterally. In particular, the supplementary motor areas were damaged, whereas the cingulum and the corpus callosum were spared. His steps were irregular and hampered by several inappropriate and incongruous movements; he also showed gait ignition failures and some instability in maintaining his upright stance. On the other hand he kept his trunk upright while walking and arm swinging was preserved. The suspicion of GA was raised and formally tested. His GA was formally assessed 14 months after his stroke. The GA test includes 70 items (plus six items used as run in examples) devised to assess trunk and lower limb movements and gait (Della Sala, Spinnler, and Venneri, unpublished data). Table 1 The patient’s performance in tests assessing ideomotor, utilisation, and facial praxis abilities 14 months post-onset Test Patient score Scale score range Cut off score Ideomotor apraxia right hand* Ideomotor apraxia left hand* Utilisation apraxia† Upper face apraxia‡ Lower face apraxia‡ 72 65 120 41 433 0–72 0–72 0–120 0–45 0–435 53 53 60 38 400 *De Renzi et al78; †De Renzi and Lucchelli68; ‡Bizzozero et al80; Della Sala et al.81 www.jnnp.com The items included in the GA test have been grouped according to the anatomical district tested. The trunk component of the test includes 22 items (for example, “Anterior flexion of trunk”, “Turn from prone to supine”). The walking component includes 20 items (for example, “Walk on the spot”, “Walk to the right whilst facing forward”) and 28 items form the lower limbs component (for example, “Slide left leg backward while seated”, “Trace a clockwise circle on the floor using your right foot”). Each item was demonstrated and orally described by the examiner. The patient had to respond by imitation immediately after presentation. Items were scored as pass or fail according to a set of rules derived from previous studies of apraxia.80 Performance was rated as hit score: the higher the score the better the performance. The GA test total score therefore ranges from zero to 70 and results from the sum of scores to the three separate components. Items are failed when the general organisation of the movements is relatively preserved, but their execution lacks dexterity (for example, legs over or under lifted, stepping irregular by size, speed or direction). An item is also failed when the performance is clearly inaccurate, (for example, the patient crossed his legs while attempting to walk), or accompanied by ineffectual, parasitic movements. Cut off values were determined by assessing the performance of 182 healthy controls (Della Sala, Spinnler, and Gait apraxia 81 Table 2 The patient’s performance in the three components of the tests assessing GA 14 months after onset Test Patient score Scale score range Cut off score Age matched controls (SD) Trunk Walking Lower limbs GA total score 11 10 5 26 0–22 0–20 0–28 0–70 20 17 26 65 22 19.9 (0.4) 27.7 (0.6) 69.5 (0.7) Venneri, unpublished data). Most controls performed at ceiling in all the three components of the test. The score corresponding to the inner tolerance limit of the normal distribution was chosen as the cut off point in all tests. The patient scored poorly on all three components of the task. For example, he failed to turn his head towards the left, or to bend his trunk forward, he proved unable to turn from prone to supine on the bed. He could not mime marching on the spot nor marching sidewise to the left or to the right. He failed all attempts when asked to pretend to extinguish a cigarette while seated, to kick an imaginary ball, or to wipe his feet on a mat. His scores together with score ranges, cut off scores derived from norms, and the mean scores achieved by 26 controls aged between 60 and 69 in each component of the test, are reported in table 2. DISCUSSION Gait apraxia as a clinical entity All purposeful movements involving trunk and legs, including walking, contribute to very complex performances. Not only do they need the cooperation and coordination of several muscular districts, but they also call for perfect timing and sequencing of events, which, once learnt, become a semiautomatic performance. Several neurological diseases and psychiatric conditions can impair this complex, skilful performance. The impairment of locomotion not accountable for by any alternative cause, coupled with cerebral lesions encroaching upon areas known to be involved in its accomplishment, should be considered GA. Gait apraxia is defined as the loss of monitoring of the automatic implementation of gait mechanisms. Gait apraxia has a long history. However, its precise nature and localisation are still defiant of exact identification. The case of the patient reported in this paper helps refine the syndrome, thanks to the standardised tests employed, and allows for a more accurate topographical definition of the responsible brain lesion, because of the unusual anomaly of his anterior cerebral arteries system. The patient never showed any problems in negotiating difficult walks (for example, mountain routes) before his stroke. We interpreted his clinical picture as apraxic because of the lack of overt elementary motor, ataxic, or psychiatric deficits. He presented with disturbances in all the domains of GA acknowledged by Zingerle28 and by Nutt et al,20 as the core symptoms of “frontal gait disorder”20—that is, walking disturbances, disequilibrium, loss of postural reflexes, counterproductive parasitic movements. He also manifested ignition failure with his feet glued to the floor,12 his walk was stiff and graceless and characterised by difficulty in stopping and turning. This paramount inability to halt one’s own gait was described by Brun58 (case H) as being similar to that of an automaton (“glich völlig einer lokomotorischen Maschine”, translation: he was akin to an automaton, p 215). Moreover, the patient failed to reproduce by imitation or on verbal command meaningful gestures (for example, a cross, a circle) with either his leg or foot, a sign seen by other authors in patients affected by GA.19 Anatomical remarks Table 3 summarises the 49 cases we could glean from the literature reporting the localisation of GA. In 45 of these cases the localisation was precise enough to contribute to our discussion. Different authors used different labels to describe similar sets of GA signs. Moreover, they chose to emphasise different aspects of the syndrome, often according to their theoretical frame of reference. The localisation is reported as given by the authors*. From the analysis of table 3 it is possible to deduce that GA is not a rare entity and can be due to different aetiologies. However, cases of “pure” GA are scant. With few exceptions (for example, case K57) the lesion damaged the precentral aspects of the frontal lobes, with or without involvement of the genu of the corpus callosum. In 24 cases out of 45 in which the localisation was possible the lesion was bilateral. When the lesion was reported as unilateral, there seems to be some evidence for a left asymmetry (13 left cases versus eight right). Indeed, Lange27 stated that “certainly frontal lobe lesions play a key role in GA, yet it would be premature to maintain that left frontal lobe lesions are more frequently associated with GA than the right ones, and which region is more important”**. Kleist26 came to the same conclusion on the basis of his review of the literature and stated that the lesion responsible for GA is located “at the foot of F1, . . .; the role of the corpus callosum is uncertain”. Scrutiny of the descriptions of the cases reported in table 3 (tumours and abscesses) discloses that the medial aspects of the frontal lobes are involved in most of them. Accordingly, Frazier49 reported that 49% of 105 cases of patients with a frontal tumour upon whom he operated showed one or more “pseudocerebellar” signs of “frontal ataxia” (p 548). He also maintained that in most cases the lesions occupied the superior aspects of the frontal lobes, whereas none encroached upon the olfactory groove or the frontal poles. However, the growth of malignant tumours permits only flawed localisation. Stroke and injury cases (table 3) should allow for a better relation between symptoms and site of lesion. Unfortunately, in several cases, the information available is too gross to attempt any fine grained localisation. Only three cases describe with some certainty a circumscribed lesion of the medial aspects of F1 (case K8; case JS56; case HP19). In some further cases the corpus callosum was damaged, pointing to medial lesion (case T57; case 166). Moreover, von Monakow18 (pp 547–52) reported on the case of patient Koch affected by a post traumatic cyst invading the whole left frontal lobe but F1. This woman did not show GA, upholding the view that GA be associated with F1 lesions. Gait apraxia has been mentioned also in three cases affected by Pick’s disease (case Zorn8 27; case AC25), one affected by notdefined brain atrophy (case Gloor8), and two with neurosyphilis (case LS84; case No 223). All these cases had a predominantly frontal atrophy, further emphasising the association between GA and frontal damage. Moreover, Rossor et al37 described GA in two demented patients reporting also PET data showing clear medial frontal hypometabolism in both patients. Lastly, some indirect evidence supporting the frontomedial hypothesis of GA comes from the finding that gait abnormalities associated with normal pressure hydrocephalus have been ............................................................. *The six patients with gait ignition failure reported by Atchison et al12 are not listed in table 3 because the authors explicitly maintain that the symptom they describe should be differentiated from GA. However, the authors acknowledged that gait ignition failure is due to frontal damage. We see no reasons to keep it separate from other manifestations of GA. **”Sicherlich spielt auch fuer sie das Stirnhirn eine wesentliche Rolle, ob das linke vorwiegend und in welchen besonderen Anteilen, läβt sich noch nicht näher feststellen”.27 www.jnnp.com 82 Della Sala, Francescani, Spinnler Table 3 Localisation of lesions of patients presenting with signs compatible with the diagnosis of GA gleaned from the literature and subdivided according to aetiology Author(s), year Traumas: Feuchtwanger 1923110 Kleist 19348 Tumours and abscesses: Bruns 189214 van Vleuten 190797 Hartmann 190754 Vincent 191146 Brun 192158 von Monakov 191418 Dimitz and Schilder 192260 Pötzl 192429 Marie et al 1924111 Gerstmann and Schilder 192622 Klein 192844 Adie and Critchley 1927112 van Bogaert and Martin 19292 Sittig 19291 Kleist 19348 Bell,1934113 Frazier 193649 Petrovici 196825 Strokes: Liepmann 1900 (quoted by Lange 193627) Abraham 190756; Brun 192158 Westphal 190715 Kleist 19076 Kroll 191057 Bonhöffer 191419 Mingazzini and Ciarla 192066 Schuster and Pinéas 192699 Maas and Sittig 1929114 Zingerle 193428 Ethelberg 1951115 Meyer and Barron 196023 Petrovici 196825 Nutt et al 199320 Case Age Sex Localisation A.Li MK K 32 20 NR M M M Metal splinter in the L and R F Bullet in the R F Bullet through L and R areas 6+gCC I II III IV AL WF Th H E W MW HK NR 54 36 60 55 57 54 25 59 58 38 18 MH FW JG AL RB MK M S LD CP 5 MA 56 56 52 54 47 34 39 NR NR 53 31 4 28 NR M M M M M W M W W W W M M M M M W W F NR NR W W M M “Sarcoma” L and R medial F Large subdural haematoma L F “Sarcoma” L F2. Glioma R F2, F3 “Sarcoma” L gCC+L F1+L cingulum Glioma gCC+L and R+cingulum Glioma RF Glioma R medial F+CC Glioma L medial F1+gCC+R cingulum Metastases medial L and R F+gCC Glioma L and R F1 F3 polar+gCC Abscess R F polar Glioma R F polar Glioma R F1, F2 Glioma L medial F Glioma R F+basal ganglia Glioma R F1 Abscess L F1, F2 Glioma L F orbitopolar Tumour around CC Glioma R F1 (area 6), L F1+CC Glioma L and R F1+gCC Glioma R F+gCC Granuloma anterior CC+hydrocephalus Fibroblastoma of the falx L and R Astrocitoma L F* T JS NR NR K T HP 1 ML AR MP 27 1 4 7 IF MM NR NR NR 48 58 58 44 49 45 51 60 70 70 61 59 71 49 59 70 63 83 68 81 M M M M M M M M W W M W M M M W M M M M L* L: TPO+F1+CC R: F and L: O+Th L and R: F* L: supramarginal and angular gyri. L: F2+supramarginal girus+gCC L: F1, F2+orbital+CC R: internal capsule+L gCC L* L and R.* L and R.* ACA atherosclerosis (angiography) L>R+hydrocephalus Anterior L and R* ACA L and R* ACA L and R.* ACA L* Multiple infarcts L and R* Multiple strokes* Periventricular vascular disease* NR *Postmortem not available; ACA, anterior cerebral artery; CBD, corticobasal degeneration; CC, corpus callosum; F, frontal; F1, F2, F3, first, second, third frontal gyrus; gCC, genu corpus callosum; L, left; R, right; TPO,temporo-parietal-occipital; NR, not reported. traced back to the compression of the areas adjacent to the frontal horns of the lateral ventricles.85–87 Neuropsychological remarks Our patient showed no deficits in any other praxis domain. His performance on tests assessing upper limb ideomotor apraxia, utilisation apraxia, and facial apraxia was well above the threshold of normality. This finding points to a dissociation between GA and other kinds of apraxia. Durwen et al41 examined the case of patient IL who had a stroke in the territory of the middle cerebral artery, and presented with oral and ideomotor apraxia but not gait apraxia, a mirror picture of that presented by our patient. They argued that for GA to emerge a lesion within the territory of the anterior cerebral artery is necessary. Moreover, several authors38–40 have argued for a relative preservation of trunk movements compared with www.jnnp.com ideomotor apraxia of the upper limbs, after parietal lesions (see further discussion in Howes42 and Poeck et al43). Taken together, these findings point to a dissociation between GA associated with frontomedial lesions and ideomotor apraxia associated with (left) parietal lesions. Indeed, lesions of frontomedial regions, in particular of the supplementary motor areas do not elicit ideomotor apraxia88 (for reviews see Laiacona et al89 andMarchetti and Della Sala90). Watson et al91 reported the only two cases of bilateral apraxia after a lesion in the left supplementary motor area of which we are aware. Only one of them (case 1) was assessed at some length. However, the patient of Watson et al showed an asymmetry in performance: 13 months after the lesion, his apraxia was present only on the left hand,92 which leaves us with the suspicion that this patient’s apraxia might be due to a lesion of the corpus callosum. The other patient with a supplementary Gait apraxia motor lesion studied in some detail had a crossed apraxia,90 and therefore the rarity of her praxis organisation should be considered with some caution. A careful analysis of case reports describing patients with anarchic hand and lesions to the supplementary motor areas93 showed that ideomotor apraxia is extremely rare, if at all present. On the contrary, fleeting comments concerning difficulty that patients with anarchic hand may have controlling their gait or leg movements abound.90 93 These problems have been sometimes labelled (bilateral) “alien foot”,94–96 although their resemblance to GA symptoms is staggering. The opposite situation is also encountered: patients are reported showing a paramount GA who also presented with clear episodes of anarchic hand behaviour. For example, Van Vleuten97 related that his patient AL (table 3) while being examined could not refrain from compulsorily unbuttoning his shirt with his left hand even when instructed not to do so. Kleist6 (table 3) also described a patient with multiple frontal strokes who was unable to inhibit endless spontaneous movements of his right hand which interfered with the actions he was requested to carry out. Our patient had a bilateral supplementary motor area lesion and, besides his overt GA, presented with a clear utilisation behaviour syndrome, which has been interpreted as a double anarchic hand.74 In summary, lesions to one supplementary motor area could give rise to contralateral anarchic hand and contralateral GA (which, however, will be clinically hard to detect as such given that the nature of the actions performed require bilateral cooperation). Bilateral lesions to the same areas might produce utilisation behaviour and a full blown GA. Moreover, lesions to the medial areas of the frontal lobes are also likely to be associated with grasp reflex (tonische Perseveration des Greifen16; Zwangsgreifen98; Nachgreifen68 99) which our patient showed from onset and throughout the follow up. On the other hand, ideomotor apraxia would be seen mainly after left parietal lesions.100 The problem remains of the possible compensatory mechanism from the intact hemisphere in unilateral cases. Follow up studies of GA are rare. Our patient was still severely apraxic over a year after his stroke. The only other case with a longitudinal follow up we could cull from the literature is that of patient FZ described by Zingerle.28 He was a 79 year old man, with alcoholism, arsenic poisoning, and possibly a right hemispheric stroke, whose severe GA improved considerably after a few months. The possibility that a unilateral GA might get better, whereas a bilateral one would not should remain speculative at this stage. A cognitive interpretation The puzzle of GA interpretation has haunted early authors and has yet to be resolved.20 Hartmann54 maintained that the frontal lobes contain a “Merkzentrum für die höhere Koordination der Bewegungsbilder” (an attention centre for the coordination of movement representations). Gerstmann and Schilder22 and Klein44 revamped the concept of gliedkinetische Apraxie15 (also known as “innervatory”6 “cortical”17 “melo-kinetic”101 or “limb-kinetic”,102 103) to account for GA. Bonhöffer,19 Denny Brown,9 and Meyer and Barron23 claimed it to be due to a contralateral frontal lesion. Kleist8 (p 952, table 3) maintained that area 6 contained a centre for the organisation of complex movements performed with trunk and lower limbs, such as dancing, hopping, or swapping the bearing of a walk. He also argued that this centre was non-lateralised (see also Liepmann5 pp 97–9). The link between supplementary motor areas and innervatory patterns has been recently advocated by Rothi et al104 105 though referring it to a mechanism necessary to code any gesture output lexicon into a space-time supramodal plan. Our patient shows GA coupled with utilisation behaviour.74 We held his bilateral supplementary motor areas lesion 83 responsible for both motor disturbances. Among their other functions106 the two supplementary motor areas would supervise two apparently heterogeneous tasks—namely, locomotion and context independent utilisation. We support the hypothesis that bilateral GA, as found in our patient, should be considered a “motor” rather than an “ideomotor” apraxia. In fact, his deficits were present in all attempts independent of the context and not only on imitation. Finally, we contend that GA has its own specificity, the diagnosis of which is possible only after having excluded other possible causes of gait disturbances. To account for this specificity we capitalise on a hypothesis put forward by Pötzl.29 He deemed that the change of the locomotor technique from four to two footed upright position, was paralleled by the phylogenetic enlargement of the frontal cortex (Fuster107 pp 174–81). He also reckoned that the coordination of gait in humans piggybacked on this process, and the frontal lobes took it over. This could have given rise to an anatomical segregation of praxis abilities. Those devoted to hand movements and the skilful use of tools would be centred on the left parietal lobe. Those required for the complexity of the mostly automatic gait movements would be carried out by the frontal lobes, in particular by the supplementary motor areas, which in this frame would serve a self monitoring function.108 ACKNOWLEDGEMENTS We thank Reiner Kashel who helped us by tracing some of the early German papers and Ian Deregowski who helped us to translate the paper by Crigel and Arseni from Russian. We are also grateful to Edoardo Boccardi who performed the angiography and helped us interpret the MRI, to Alessandra Maietti who helped us map them onto the templates, and to Cristina Motto, under whose care our patient was. Angela Bartolo helped us organise the early literature. ..................... 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