NIH Public Access Author Manuscript J Neuropsychiatry Clin Neurosci. Author manuscript; available in PMC 2011 March 16. NIH-PA Author Manuscript Published in final edited form as: J Neuropsychiatry Clin Neurosci. 2010 ; 22(4): 451–t.e34-451.e35. doi:10.1176/appi.neuropsych. 22.4.451-t.e34. PROGRESSION OF VASCULAR DEPRESSION TO POSSIBLE VASCULAR DEMENTIA Santosh Loganathan, MD, Vivek Phutane, MD, Om Prakash Jhirwal, MD, and Mathew Varghese, MD Department of Psychiatry National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, Karnataka, INDIA. Keywords Vascular depression; cognitive deficits; white matter abnormalities; sub-cortical grey matter hyper intensities; vascular dementia. NIH-PA Author Manuscript To the Editor: The concept of vascular depression includes depression, vascular disease, vascular risk factors and the association of ischemic cerebral lesions to behavioral symptoms. {1} Memory deficits are known to occur during depression: deficit in recollecting stored information in a depressed individual is known as ‘pseudo dementia’. Secondly, older adults with depression have an increased risk of developing mild cognitive impairment (MCI) which seems to be independent of underlying vascular disease. {2} Thirdly, older adults with depression also have an increased risk of developing dementia, but whether that risk is enhanced on a background of cerebral vascular pathology is still unclear. {3} We strive to clarify this uncertainty with this report. Case report NIH-PA Author Manuscript Mrs. S is a 51 year old lady, known to have hypertension, hyper-lipidemia, double vessel coronary artery disease and carotid vessel disease since 8 years, being treated with amlodipine, losartan, atorvastatin, clopidogrel and aspirin. She presented with a continuous illness of 2 years characterized by pervasive sad mood, decreased energy, hopelessness, early morning awakening, worsening of mood in the morning, loss of appetite and loss of taste. Memory disturbances and significant impairment in functioning surfaced 6 months prior to consulting us. She had been treated with an adequate trial of nortryptiline and pramipexole with a partial response; adequate trial of escitalopram and trazodone (including augmentation with quetiapine) with no response. We identified a family history of bipolar illness in her sister, hypertension and ischemic heart disease in both her parents and maternal uncle. On mental status examination, she was depressed (HDRS score: 32) and had memory deficits. In view of the cerebral lesions, a diagnosis of an organic depressive disorder was made according to ICD-10. Conceptually vascular depression was considered with the possibility that it may be progressing to vascular dementia. MRI of brain revealed multiple white matter abnormalities (hyper intensities) in bilateral frontal, parietal-occipital white matter, bilateral lentiform nuclei and head of right caudate and right thalamus. (Figure 1) In view of cognitive deficits, she was subjected to a CORRESPONDING AUTHOR: Dr. Santosh Loganathan, MD. Phone: +1 314-286-2272 santoshl_28@yahoo.co.in. ADDRESS FOR REPRINTS: Mathew Varghese, MD, Professor of Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029 INDIA.. Loganathan et al. Page 2 NIH-PA Author Manuscript neuropsychological assessment, after her depressive symptoms remitted to avoid false positive findings. She had impaired motor speed, verbal and visual working memory, decreased speed of processing and category fluency. Immediate recall was impaired, but she benefitted from recognition testing. She was treated with gradual increasing dosages of Mirtazapine tablets from 15mg per day to 60 mg per day which later required augmentation with 150 mg of Bupropion tablet once a day. Her anti-hypertensive was changed from amlodipine to nimodipine capsules 180 mg per day. She was then started on 5 mg of Donepezil tablets at bedtime. Discussion NIH-PA Author Manuscript The diagnosis of vascular depression was evident with pervasive depressed mood occurring on a background of a family loading of vascular risk factors, cerebrovascular risk factors and cerebral vascular pathology. To confirm the diagnosis we used a modified Fazekas classification system, which provides an estimate of the degree of deep white matter and sub-cortical grey matter hyper intensities. {4,5} According to this scale our patient scored more than 2 on both deep white matter and sub-cortical grey matter hyper intensities. It thus ruled out a differential of severe depressive disorder without psychotic symptoms. Since our patient benefitted from recognition testing, the dissociation between immediate recall and recognition probably suggests that the memory impairment were a result of a sub cortical disease process. Despite recovery from depressive symptoms, the cognitive deficits were irreversible at 5 months follow up with persisting impairment of functioning, which convinced the treating team about progression to dementia. According to ICD-10, the diagnosis of dementia requires the presence of both cognitive and functional impairment for at least 6 months, and our patient did not have memory deficits or functional impairment during the first one and half years of her illness. However, one may argue that dementia could have occurred earlier, but we do not have any evidence to support it. Bupropion was chosen as augmentation to antidepressant therapy as few reports mention usefulness in vascular depression. {6} Nimodipine replaced amlodipine, as its role in augmentation with antidepressant therapy for vascular depression is known to cause greater fall in depressive symptoms. {7} Donepezil was added due to its growing efficacy in vascular dementia. {8} NIH-PA Author Manuscript Though we know that depression in the elderly can progress to dementia, we are still in the dark as to who among them are prone to do so. This case underlines the fact that cerebral vascular pathology may be a common factor linking such a progress. The fact that the depression was resistant to treatment could also emphasize the organic nature of the disorder. Though our patient did not have a stroke, familial risk factors and cerebral vascular lesions were contributory to vascular depression. There is a need to understand the natural course of patients with pure vascular lesions without any history of stroke. Follow up of those who develop dementia, factors influencing such a progress and the rate of such a progression is also necessary. This case illustrates that managing depression in the elderly may not suffice by treating depression alone but also being vigilant about the various possibilities that could arise. Acknowledgments The authors would like to thank the patient and her family for providing consent for this case report. There was no financial assistance relevant to the manuscript. References 1. Alexopoulos GS, Meyers BS, Young, et al. Vascular depression hypothesis. Arch Gen Psychiatry. 1997; 54(10):915–22. [PubMed: 9337771] J Neuropsychiatry Clin Neurosci. Author manuscript; available in PMC 2011 March 16. Loganathan et al. Page 3 NIH-PA Author Manuscript 2. Barnes DE, Alexopoulos GS, Lopez OL, et al. Depressive Symptoms, Vascular Disease, and Mild Cognitive Impairment. Findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006; 63:273–280. [PubMed: 16520432] 3. Jorm AF. History of depression as a risk factor for dementia: an updated review. Aust N Z J Psychiatry. 2001; 35:776–781. [PubMed: 11990888] 4. Krishnan KRR, Hays JC, Blazer DG. MRI-Defined vascular depression. Am J Psychiatry. 1997; 154(4):497–501. [PubMed: 9090336] 5. Sneed JR, Rindskopf D, Steffens DC, et al. The vascular depression subtype: evidence of internal validity. Biol Psychiatry. 2008; 64:491–497. [PubMed: 18490003] 6. Steffens DC, Taylor WD, Krishnan KRR. Progression of Sub cortical Ischemic Disease from Vascular Depression to Vascular Dementia. Am J Psychiatry. 2003; 160:1751–1756. [PubMed: 14514484] 7. Taragano FE, Allegri R, Vicarioet A, et al. A double blind randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of vascular depression. Int. J. Geriatr. Psychiatry. 2001; 16:254–260. [PubMed: 11288158] 8. Black S, Román GC, Geldmacher DS, et al. Efficacy and Tolerability of Donepezil in Vascular Dementia. Positive Results of a 24-Week, Multicenter, International, Randomized, PlaceboControlled Clinical Trial. Stroke. 2003; 34:2323–2332. [PubMed: 12970516] NIH-PA Author Manuscript NIH-PA Author Manuscript J Neuropsychiatry Clin Neurosci. Author manuscript; available in PMC 2011 March 16. Loganathan et al. Page 4 NIH-PA Author Manuscript NIH-PA Author Manuscript Figure 1. T2 weighted FLAIR image showing multiple white matter abnormalities (hyper intensities) at left frontal, bilateral parietal, occipital white matter. Also noted are sub-cortical grey matter hyper intensities in head of right caudate nucleus and bilateral lentiform nuclei. NIH-PA Author Manuscript J Neuropsychiatry Clin Neurosci. Author manuscript; available in PMC 2011 March 16.