Surgical and Radiologic Anatomy https://doi.org/10.1007/s00276-019-02318-4 ANATOMIC VARIATIONS A case of right internal carotid agenesis with associated transcavernous anastomosis revealed by transient ischemic attack Benjamin Hebant1 · Emmanuel Gerardin2 · Céline Delpierre2 · Jean‑Loup Mereaux1 · Gerald Quesney1 · Romain Lefaucheur1 Received: 8 February 2019 / Accepted: 30 August 2019 © Springer-Verlag France SAS, part of Springer Nature 2019 Abstract Agenesis of the internal carotid artery (ICA) is a rare congenital vascular disorder of the cerebral circulation. CT scan of the skull base disclosing complete absence of the bony carotid canal helps to differentiate an agenesis from aplasia or hypoplasia. Although most of the patients remain asymptomatic (thanks to the sufficient collateral circulation provided by the circle of Willis) cerebral infarcts, transient ischemic attacks or intracranial aneurysms have been rarely described in association with agenesis of the ICA. Most often, the vascular territory of the involved ICA is supplied by the contralateral carotid artery and from the vertebrobasilar circulation through the anterior and posterior communicating arteries, respectively. However, collateral supply can also be provided thanks to a transcavernous anastomosis, an aberrant vascular communication between the cavernous portions of the ICAs coursing through the sella turcica. We report here the case of a 55-year-old man with right carotid agenesis and associated transcavernous anastomosis revealed by transient ischemic attack. Embryogenesis, imaging findings, possibilities of collateral circulation and potential complications have also been discussed. Keywords Internal carotid artery agenesis · Transcavernous anastomosis · Transient ischemic attack Unilateral anomalies of the internal carotid artery (ICA) related to developmental defects include agenesis, aplasia and hypoplasia. In case of agenesis, both ICAs and bony carotid canal are absent [8]. These rare congenital anomalies occur in less than 0.01% of the population [1, 12], and are most often incidentally discovered on color doppler ultrasonography, magnetic resonance imaging (MRI) or computed tomography of the head and neck vessels. Although most patients remain asymptomatic (thanks to the sufficient collateral circulation provided by the circle of Willis), transient ischemic attacks or cerebral infarcts can occur as well as cerebral haemorrhages due to ruptured aneurysms [6, 7]. Most often, vascular supply of the involved ICA is provided thanks to the circle of Willis (through the anterior and posterior communicating arteries). However, much less commonly, collateral flow is provided by a transcavernous anastomotic vessel between the ICAs and coursing through the sella turcica. We report here the case of a patient with right ICA agenesis and associated transcavernous anastomosis (TA), revealed by a transient ischemic attack (TIA). * Benjamin Hebant benjamin.hebant@gmail.com Case report Abbreviations ACOM Anterior communicating artery ACA​ Anterior cerebral artery CCA​ Common carotid artery ECA External carotid artery ICA Internal carotid artery MCA Middle cerebral artery PCOM Posterior communicating artery TA Transcavernous anastomosis TIA Transient ischemic attack Introduction 1 Department of Neurology, Rouen University Hospital and University of Rouen, 76031 Rouen Cedex, France 2 Department of Neuroradiology, Rouen University Hospital and University of Rouen, Rouen Cedex, France A 55-year-old man with past medical history of tobacco abuse and hypertension was referred for a sudden episode of left hemibody paresthesias during 1 hour. Clinical 13 Vol.:(0123456789) Surgical and Radiologic Anatomy examination showed a blood pressure of 90/60 mmHg and an isolated left hemibody hypoesthesia. Color doppler sonography disclosed a smaller caliber of the right common carotid artery (CCA) in comparison to its opposite, the right ICA could not be observed, and we noted a changing flow pattern of the right CCA from a low peripheral resistance pattern into a high one, as observed in external carotid artery (ECA) in distality, suggesting that the right CCA only led to the right ECA. MRI with diffusion-weighted imaging sequence showed no recent infarction. 3D contrast-enhanced MR angiography sequence showed the reduced caliber of the right CCA and the absence of the right ICA (Fig. 1a). 3D time of flight MR angiography confirmed the absence of flow-related signal within the right ICA. Both anterior cerebral arteries (ACAs) originated from the left ICA (the right A1 segment is not seen). An intracavernous collateral vessel arising from the contralateral ICA and coursing through the sella turcica supplied the right carotid siphon and the right middle cerebral artery (MCA). The posterior communicating arteries (PCOM) could not be seen (Figs. 1b, c, 2a). There was no associated venous intercavernous sinus. CT scan of the skull base disclosed complete absence of the right bony carotid canal confirming the congenital agenesis of the right ICA (Fig. 2b). The diagnosis of low-flow TIA triggered by right ICA agenesis was suspected. The antihypertensive medication of Fig. 1  Brain MRI. a 3D contrast-enhanced MR angiography showed a smaller caliber of the right CCA than the left one (arrowheads) as well as the absence of the right ICA. The right CCA only led to the right ECA (arrow). b, c 3D time of flight MR angiography confirmed the absence of flowrelated signal within the right ICA. Note the presence of an aberrant transcavernous vessel between the cavernous portions of the ICAs coursing though the sella turcica to supply the right carotid siphon and the right MCA (arrowheads). Note that the circle of Willis is incomplete with bilateral aplasia of the PCOMs and the A1 segment of the right ACA. Both ACA originated from the left ICA 13 the patient was adapted allowing a favourable clinical course without symptoms recurrence. Discussion We report a symptomatic case of unilateral agenesis of the right ICA with a TA anastomosis, a very rare developmental disorder. Dysgenesis of the ICA, which include agenesis, hypoplasia or aplasia, is usually fortuitously discovered by Doppler ultrasonography or brain imaging performed for other reason. According to Lie, agenesis correspond to a total absence of the organ due to failure of the artery to develop embryologically, whereas aplasia refers to a lack of organ development but with existence of its precursor and hypoplasia correspond to incomplete organ development [8]. Agenesis of ICA was firstly described by Tode in 1787 (on postmortem examination) [14] and although both can be involved, the cases described in the literature predominate slightly in men and on the left side [4]. Intracranial circulation is maintained by collateral circulation allowing patients to stay mostly asymptomatic. According to Lie, six patterns (type A to F) of collateral circulation in association with ICA absence were described. Among them, we count three pathways of collateral circulation associated with unilateral ICA agenesis (classified into Type A, B or D). In type A (the most common), ipsilateral MCA is supplied from the vertebrobasilar circulation Surgical and Radiologic Anatomy Fig. 2  a Sagittal image of a CT angiogram also showed the intrasellar intercarotid communicating artery (arrowhead). b Axial image of a CT angiogram at the level of the petrous ICA demonstrated the absence of both right ICA and bony carotid canal (black arrow) confirming the diagnosis of right ICA agenesis. The left ICA and bony canal are present and normal (white arrow) through an hypertrophied PCOM and ipsilateral ACA from the anterior circulation through a patent anterior communicating artery (ACOM). In type B, both ipsilateral MCA and ACA are supplied via a patent ACOM. The less common (as in our patient) is the type D in which the ipsilateral carotid siphon received blood flow through a transcavernous vessel arising from the contralateral ICA and coursing through the sella turcica [8]. Embryological segments of the ICA are derived from the dorsal aorta and the third aortic arch at the 3-mm embryonic stage; whereas, the circle of Willis develops later (7-mm to 24-mm embryonic stage). The ICA development occurs before skull base formation. The presence of an ICA is necessary for the formation of the bony carotid canal, explaining that in case of ICA agenesis, the ipsilateral carotid canal is absent [9]. Consequently, blood supply is more likely through the circle of Willis if the disruption occurs after 24-mm embryonic stage, or through a TA if it occurs earlier [2]. In our case, the existence of a TA between the carotid siphons confirmed the congenital absence of the right ICA. Moreover, the lack of the right carotid canal allowed to differentiate agenesis from aplasia. The embryological explanation of this abnormality is controversial, because it has never been observed in developing embryo [8]. This anastomotic vessel may arise from a union between two primitive trigeminal arteries that have lost their communication with the basilar artery, or from the persistence or hypertrophy of embryologically developing vessels (remnant of the primitive maxillary artery or via the plexiform network of vessels, described by Padget, which originates from the ICAs and communicates with one another around Rathke’s pouch) [3, 8, 9]. These different theories account for the variable courses of the intercavernous communications which can be intrasellar (as in our case), transsphenoidal, paraclinoid–supraclinoid or supraclinoid–supraclinoid. Anastomosis between the paraclinoid or supraclinoid segment of the ICA and the supraclinoid segment of the other ICA so-called paraclinoid–supraclinoid or supraclinoid–supraclinoid anastomosis has been rarely reported. These types of supracavernous anastomoses which did not correspond to a previous type of Lie’s classification are considered to be an unusual variation of type D anastomosis [5, 15]. The coexistence of several types of collateral circulation in a same patient such as a paraclinoid–supraclionoid anastomosis and an anastomosis between the tip of the basilar artery and the PCOM has also been reported [15]. An another congenital anomaly described is the absence of the left CCA with separate origin of the ECA and ICA from the aortic arc (in this case, the left ICA originates from the brachiocephalic trunk (bovine origin) and the left ECA arose from the aortic arc [11]. Patients with Lie’s type D anastomosis have also a higher incidence of anterior communicating aneurysms. Such patients should also be followed up radiologically not only to check for enlargement of the existing aneurysms but also to detect new ones. It appears particularly important to diagnose these anatomical variants prior to neurosurgical approaches such as transsphenoidal or transcranial, to avoid damaging these arteries [6]. Although patients often have no symptoms, cerebral infarctions or TIA [7] has been rarely reported, as well as an 13 Surgical and Radiologic Anatomy increased incidence of intracranial aneurysms in case of ICA agenesis or hypoplasia [6]. Two hypotheses exist to explain this association: both conditions could occur independently during embryonic life as a result of a developmental error operating at both loci or the aneurysm may be secondary to the deranged hemodynamic forces induced by the absence of the contralateral ICA [13]. The existence of multiple associated intracranial artery segmental agenesis or aplasia is not rare [10]. Note that in our patient, in contrary to the initial description by Lie, the A1 segment of the ipsilateral ACA was absent. Consequently, both ACA originated from the contralateral ICA and the ipsilateral MCA territory is only supplied by the TA. The complete anterior circulation, therefore, depends entirely on a single carotid artery, which makes it particularly vulnerable to atherosclerotic disease involving the sole CCA or ACI. Author contributions BH: manuscript writing. EG: critical revision of the manuscript. CD: critical revision of the manuscript. JLM: critical revision of the manuscript. GQ: critical revision of the manuscript. RL: critical revision of the manuscript. Funding No targeted funding reported. The study is not industry-sponsored. Compliance with ethical standards Conflict of interest The authors declare that they have no conflict of interest. Informed consent Informed consent was obtained from all individual participants included in the study. Ethical approval Financial disclosures the authors report no disclosures relevant to the manuscript. 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