Park et al. BMC Neurology (2023) 23:370 https://doi.org/10.1186/s12883-023-03363-8 BMC Neurology Open Access CASE REPORT An interesting case of crossed syndrome: ipsilateral facial paralysis with contralateral glossoplegia Sangil Park1†, Su Hyeon Ha1†, Baeseoup Song1, Ho Geol Woo1, Sung Hyuk Heo1 and Dae-il Chang1* Abstract Background Stroke is rarely accompanied with peripheral facial paralysis and supranuclear palsy of the hypoglossal nerve. Both sides of the motor cortex innervate the hypoglossal nucleus; therefore, unilateral lesions of the upper motor neurons rarely result in contralateral lingual paresis. We report a rare case of crossed syndrome with associated hyperacute peripheral hemifacial paralysis and contralateral lingual paresis after a lower pontine tegmentum ischemic stroke. Case presentation : A 73-year-old man presented with symptoms of hyperacute peripheral hemifacial paralysis. Upon protrusion, the patient’s tongue deviated to the contralateral side, without fasciculation or atrophy. Brain imaging showed focal ischemic stroke in the pontine tegmentum. However, lingual hemiparesis and multimodal neuroimaging findings differed. Conclusions We suggest that cortico-hypoglossal fibers pass through the dorsal pontine. This case of crossed syndrome is a rare report of a lower pontine tegmentum ischemic stroke resembling an upper motor neuron lesion of the contralateral hypoglossal nerve. Keywords Crossed syndrome, Hypoglossal nerve, Glossoplegia Background Crossed syndrome is a form of hemiplegia with ipsilateral cranial nerve palsy and contralateral hemiplegia of the extremities, resulting from a unilateral brainstem lesion [1]. Lingual hemiparesis can result from damage to the hypoglossal nerve (lower motor neurons) and supranuclear innervation [upper motor neuron] [2]. Both sides of the motor cortex innervate the hypoglossal nucleus; † Sangil Park and Su Hyeon Ha contributed equally to this work. *Correspondence: Dae-il Chang dichang@khmc.or.kr 1 Department of Neurology, Kyung Hee University Hospital, #23 Kyunghee-daero, Dongdaemun-gu, Seoul 02447, Republic of Korea therefore, unilateral lesions of upper motor neurons rarely result in contralateral lingual paresis [3]. Supranuclear lesions commonly result in central facial and lingual paralysis, while crossed paralysis is a relatively uncommon symptom. Herein, we report a rare case of crossed syndrome with associated hyperacute peripheral hemifacial paralysis and contralateral lingual paresis after lower pontine tegmentum ischemic stroke. Case Presentation A 73-year-old man presented with a sudden onset of left facial paralysis. Patient visited the emergency department 5 h after the onset. The patient was on medication for hypertension, which was diagnosed several years prior; and the patient was a heavy smoker. The patient © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Park et al. BMC Neurology (2023) 23:370 had no apparent history of head or neck trauma. Neurological examination revealed profound left peripheral facial paralysis (Fig. 1A, B). Upon protrusion, the tongue deviated to the right, without fasciculation or atrophy. However, the tongue’s range of motion was normal at rest and did not protrude in any direction (Fig. 1C-H). It was suspected that there was a lesion in the upper motor neuron of the left hypoglossal nerve. An intraoral examination revealed no abnormalities in the uvula or palate. No complaints of swallowing difficulty or any motor or sensory impairments of the extremities. Although the patient’s blood pressure was high (169/89 mmHg), other vital signs were stable. Acute left caudal pontine stroke was suspected, and a neuroimaging diagnostic workup was performed immediately. Initial brain computed tomography revealed no ischemia or hemorrhagic lesions. However, brain magnetic resonance imaging revealed a focal hyperintense lesion in the left pontine tegmentum on diffusionweighted imaging (Fig. 2A). A low signal intensity on the apparent diffusion coefficient map demonstrated that the lesion was an acute ischemic infarction (Fig. 2B). Therefore, we determined that the lesion affected the upper motor neuron of the right hypoglossal nerve and the lower motor neuron of the left facial nerve. Page 2 of 4 Occlusions were observed in the fourth segment of the vertebral and basilar arteries, as identified by magnetic resonance angiography (Fig. 2C). Although the occlusions were initially attributed to large artery atherosclerosis, considering other etiologies, including cardioembolic causes, is important. Transthoracic echocardiography, 24-hour Holter monitoring, and transcranial Doppler ultrasonography-bubble test were performed, but no other embolic causes were identified. The lesion was relatively small in size compared to the area of occlusion and the patient experienced only mild symptoms; therefore, dual antiplatelet therapy rather than thrombectomy was recommended to prevent a secondary stroke. The patient received dual antiplatelet therapy (aspirin 100 mg/day and clopidogrel 75 mg/day) and high-intensity statin therapy (atorvastatin 40 mg/day). On the seventh day of hospitalization, the tongue deviation noticeably improved, and the patient was discharged without any worsening neurological symptoms. Discussion and conclusions The hypoglossal nucleus is located on the medial medulla, immediately below the fourth ventricle (Fig. 2D). It receives corticobulbar fibers from both hemispheres for voluntary control and is responsible for reflex Fig. 1 Left-sided peripheral facial nerve palsy and evidence of an upper motor neuron lesion. There is reduced innervation of the forehead (A), and impaired lid closure when the eye is closed (B). The tongue had a normal range of motion during movement in different directions (C-F) and at rest (G). On tongue protrusion, there is a right lingual paresis (H) Park et al. BMC Neurology (2023) 23:370 Page 3 of 4 Fig. 2 Focal acute ischemic lesion in left pontine tegmentum, axial diffusion weighted images (A) and apparent diffusion coefficient (B). There is a basilar artery occlusion on magnetic resonance imaging (C). The hypoglossal nucleus receives corticobulbar fibers from both hemispheres for voluntary control (D). We suggest a unique hypothetical cortico-hypoglossal tract (D) movements such as chewing, sucking, and swallowing [2]. However, supranuclear palsy of the hypoglossal nerve can result in motor impairment on the contralateral side of the lesion, even without atrophy or fasciculations. This is because among the extrinsic muscles of the tongue, only the genioglossus (which is responsible for tongue protrusion) crosses the unilateral innervation [4]. Therefore, if the tongue deviates only during protrusion, without atrophy or fasciculations, a lesion in the upper motor neuron on the contralateral side is likely. However, the absence of atrophy or fasciculation does not exclude the involvement of lower motor neurons. Regarding the timing of the injury, a neurological examination is necessary because it may be too early to observe atrophy or fasciculation. Corticobulbar fibers descend from the peri-sylvian area of a motor homunculus through the corona radiata, internal capsules, and cerebral peduncle to the basis pontis, and the opposite projections cross the midline at the pontomedullary junction [5]. However, dorsal pontine lesions do not involve cortico-hypoglossal projections [6]. Park et al. BMC Neurology (2023) 23:370 In previous studies, the decussation of the corticohypoglossal tract was generally located at the pontomedullary junction, and variations were due to individual differences [7, 8]. Furthermore, before decussation, cortico-hypoglossal fibers pass through the medial portion of the ventral pons and the lateral portion of the pons without crossing the midline [6]. To the best of our knowledge, this is a rare report of crossed syndrome with ipsilateral facial paralysis and contralateral glossoplegia associated with a lower pontine tegmentum ischemic stroke resembling a supranuclear lesion of the hypoglossal nucleus. We suggest that cortico-hypoglossal fibers pass through the dorsal pontine, although this occurrence is exceedingly uncommon (Fig. 2D). It is crucial to acknowledge that the presentation of symptoms can vary, contingent upon the precise location and extent of the lesion within the supranuclear pathway. Consequently, studying similar cases is of paramount importance to enhance our comprehension of the wide-ranging patterns of corticohypoglossal fiber connections and their correlation with clinical manifestations. Therefore, additional investigations involving more cases are necessary to shed light on the underlying mechanism responsible for the rare symptoms observed in our patient. If the tongue deviates to one side during protrusion, without associated atrophy or fasciculation, clinicians should consider contralateral lesions of the upper motor neurons and note that there may be various patterns of cortico-hypoglossal fibers. Furthermore, the possibility of acute stroke should not be excluded in older patients, patients with risk factors for vascular disease, and patients who have sudden symptoms; and brain imaging studies are necessary. Acknowledgements We are thankful to the patient for the support given in providing data. Authors’ contributions Sangil Park, Su Hyeon Ha wrote the main manuscript text and prepared Figs. 1 and 2. Dae-il Chang contributed to the conception and acquisition of data, drafting, and reporting of the case. All the authors have read and approved the final manuscript. Funding No source of funding. Page 4 of 4 Data availability The datasets supporting the conclusions of this article are included in the article. Declarations Ethics approval and consent to participate Not obtained, as it was a case report. Written consent only obtained. Consent for publication Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests The authors declare no competing interests. Received: 5 March 2023 / Accepted: 17 August 2023 References 1. Silverman IE, Liu GT, Volpe NJ, Galetta SL. The crossed paralyses. The original brain-stem syndromes of Millard-Gubler, Foville, Weber, and RaymondCestan. Arch Neurol Jun. 1995;52(6):635–8. https://doi.org/10.1001/ archneur.1995.00540300117021. 2. Laine FJ, Smoker W. Anatomy of the cranial nerves. Neuroimaging Clin N Am. 1998;8(1):69–100. PMID: 9449754. 3. Lee JH, Lee D, Heo SH, Chang D-i. Isolated glossoplegia in capsular infarction. Can J Neurol Sci. 2016;43(6):843–4. https://doi.org/10.1017/cjn.2015.353. 4. Mu L, Sanders I. Human tongue neuroanatomy: nerve supply and motor endplates. Clin Anat Oct. 2010;23(7):777–91. https://doi.org/10.1002/ca.21011. 5. Im S, Han YJ, Kim SH, Yoon MJ, Oh J, Kim Y. 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